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The big winners — like Salt Lake City, San Antonio, Denver, Portland, and San Jose — are not necessarily those with the most natural advantages — a low cost of living, proximity to educational and research institutions, high-tech industries, top universities, etc. — but they have a willingness to take risks and invest their resources. Advertisement How we got to the Top 50 The EPI was created to identify where are best positioned to continue to make progress in the face of the severe economic and quality-of-life challenges posed by the twin epidemics of obesity and chronic illness. The first step in creating the EPI was to use data that tracks changes in economic, environmental, health and quality-of-life performance at the same-size-metro-area level. Next, we assessed those areas on a specific set of criteria that would be most helpful in characterizing the nation’s best performers. 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